Biological and Biomimetic Materials—Honoring Prof. A. Darvizeh

Biological and biomimetic molecular machines.

The evolution of life facilitates the creation of biological molecular machines. In these so-called 'nanomachines,' nature elegantly shows that when precisely organized and assembled, simple molecular mechanical components can link motions efficiently from the nanometer scale to the macroscopic world, and achieve complex functions such as powering skeletal muscles, synthesizing ATP and producin...

Biological and biomimetic materials and surfaces

From everyday life experience, we all know that during watering or rainfall, water rolls off the leaves of many plants in the form of spherical droplets leaving the leaves themselves entirely dry. This effect can be seen in an especially impressive manner on the leaves of the sacred lotus (Nelumbo nucifera) and Tropaeolum (Tropaeolum majus). Interestingly, with the rolling off of water droplets...

Prof. Dr. Prof. Prof.

Biomimetic synthesis and biological evaluation of Aplidiopsamine A.

The first total synthesis of Aplidiopsamine A, a rare 3H-pyrrolo[2,3-c]quinoline alkaloid from the Aplidiopsis confluata, has been achieved following the proposed biosynthesis. This biomimetic synthesis requires only five steps and proceeds in 20.8% overall yield. Biological evaluation across large panels of discrete molecular targets identified that Aplidiopsamine A is a highly selective PDE4 ...

A Letter for Honoring Prof. Takeshi Matsuura